Once Human Great Ones: Introduction
Once Human Great Ones Guide
Once Human Great Ones are formidable bosses that stand as twisted remnants of humanity’s clash with the mysterious Stardust. Each Great One presents a unique challenge, blending grotesque biology with unpredictable abilities. These aren’t just bullet sponges—they’re layered encounters requiring tactics, teamwork, and a steady hand. Whether it’s a hulking brute that smashes terrain or a nimble horror that warps space, these bosses drop powerful loot and offer a real test of your build. Prepare well, aim true, and don’t blink—these aren’t your average monsters.
In Once Human, The Great Ones are the towering nightmares born from Stardust’s twisted touch. These aren’t your average boss fights—they’re the monstrous result of humanity, wildlife, and nature itself being warped into grotesque abominations. Think of them as the final exam in terror, each one a living monument to just how far things have gone wrong. They’re not just strong—they own entire regions of the map, shaping the world around them through raw, corrupted power.
Each Great One in Once Human is more than just a bullet sponge with flashy moves. They’re a test of strategy, timing, and grit. One might bombard you with toxic spores, while another lumbers forward like a walking mountain, shrugging off anything short of heavy artillery. But don’t panic—this Once Human Great Ones guide is built to make sure you don’t go in blind. Knowing what each one can do and how they behave turns a hopeless fight into a winnable war.
The best part? They’re not invincible. With the right preparation—gear, squad tactics, and understanding each boss’s behavior—you’ll stand a real chance at taking them down. That’s where this Once Human Great Ones guide shines: giving you the info you need without drowning you in jargon or fluff. Whether you’re hunting your first Great One or trying to speedrun through them, this guide will help you do it with confidence and maybe even a grin.
Once Human Great Ones: General Tips for Facing Great Ones
Combat Tips for Boss Encounters
Tip Category What to Use Why It Matters Survival Gear Activators, Adrenaline Shots, Stamina/Speed Buffs Keep yourself alive longer, move faster, and recover from damage quickly Deviants Lone Wolf’s Whisper, Snow Globe Distracts mobs or adds effects like freeze (Snowballs can be spammed tactically) Essential Potions Living Armor (crafted from Treant’s Harvest Seeds) Grants a one-time death shield—crucial for high-risk boss encounters Boss Damage Boosts Master Tactician skill + Throwing Daggers or Snowballs Gives +25% damage to bosses for 15s; easy to trigger with throwables Recommended Weapon Recurve Crossbow + Bullseye mod Inflicts Bullseye on weak spot hits, boosting crit rate and potential vulnerability Combat Awareness Dodge, use cover, monitor boss movement Staying mobile and reactive is key to survival and successPreparing for a Great One is like prepping for a boss fight with teeth—literally. Stock up on activators, adrenaline, and any consumables that boost stamina or speed. These fights are a marathon, not a sprint, and your inventory needs to reflect that. If you’re going in light, you’re probably not coming out at all.
Tactical Deviants can turn the tide. The Lone Wolf’s Whisper distracts mobs (and sometimes bosses), and Snow Globe lets you pelt enemies with snowballs that count as tactical items—useful for triggering the Master Tactician skill. That little trick gives you a juicy +25% boss damage boost for 15 seconds, and it stacks beautifully with weapons that can exploit weak points.
This Once Human Great Ones guide also recommends carrying a Living Armor potion—it’s like having a second life. If your sanity meter shows it’s active, you’ve got one free pass before death grabs you. Pair it with a recurve crossbow tuned for swap speed and modded for Bullseye. Hit a weak point, and suddenly your whole loadout gets sharper. With gear prepped and tactics locked in, you’ll see why this Once Human Great Ones guide doesn’t just tell you to survive—it teaches you to dominate.
Once Human Great Ones: The Great Ones
Boss Name Required Level Location (Monolith) Weak Spots Key Mechanics Summary Ravenous Hunter 10 Monolith of Greed (Dayton Wetlands) Yellow sac on head Gatling shield, rocket barrage, acid spit, immunity & spawners Treant 20 Gaia Cliff (Broken Delta) Female host on back, horned head, red vines Flying orbs, lasers, pound attack, timed vulnerability Arachsiam 30 Mirage (Iron River) Purple back spots, human chest/head Web attacks, cocoons, mist phase, exploding spiders, poison mist Rabizex 40 Thirst (Chalk Peak) Head (enraged), shoulders (after 2 bars) Shadow projectiles, burrow, orbs, AoE pull, orb-phase 1-shot wipe Mensdevoran 60 Forsaken (Red Sands) Glowing palms, head, stomach (situational) Slam/sweep attacks, platform destruction, mobs, laser, grabOnce Human Great Ones: Other Noted Bosses
Boss Name Location Weak Spot Key Mechanics Summary Secret Servitor Tundra Monolith (Onyx Tundra, Almit-grade Rift Space) Head Three-headed flying octopus; Plasma Beam, Energy Burst, Shield Phase.The Secret Servitor is a formidable, three-headed flying octopus deviant found in the Tundra Monolith (Onyx Tundra, Almit-grade Rift Space). Its heads are the weak spots, and attacking them will deal the most damage. This boss utilizes several challenging mechanics, including a devastating Plasma Beam, a damaging Energy Burst, and a tricky Shield Phase that temporarily protects it. The key to defeating it lies in consistently targeting the heads while managing its high-powered attacks. Stay alert for the different phases and dodge its energy projectiles to stay on top of this fight.
Once Human Great Ones: Best Weapons Against the Great Ones
To take down the Once Human Great Ones, it’s essential to not only know their mechanics but to arm yourself with the right tools. Staying mobile and at a distance is critical—dodging attacks and keeping on your toes will be key to survival. The right weapons and gear can tilt the battle in your favor. If you want to learn more about weapons, we have a Once Human Weapons Guide.
Once Human Great Ones weaknesses are long ranged weapons. For ranged attacks, the Recurve Crossbow is highly recommended. It hits weak spots, inflicting Bullseye, which boosts your crit rate by 30%. It also allows you to add a Vulnerability mod, increasing damage dealt to the boss by 8%. The blueprint is found in a mystical crate at the Bell Tower near the Evergreen Rift anchor. For armor, consider the Renegade set, which can stack damage up to 40%. If you prefer crit-heavy setups, the Falcon set boosts your crit damage and rating significantly.
HAMR – CRUMBLE B.P. Weapon TypeSniper Rifle RarityRare StyleJuggernaut Durability100 Stats DMG17585 Crit Rate2% Weakspot DMG80% Crit DMG30% Weapon Features- 60% chance to trigger Burn with a weakspot hit.
- Burn DMG +10%
HAMR – CRUMBLE B.P.
As mentioned earlier, the HAMR Crumble Sniper Rifle is a top pick for long-range precision. It delivers high damage with a solid crit rate and works great when combined with Vulnerability mods. Its range allows you to stay out of harm’s way, making it ideal for taking down bosses that require strategic positioning.
- Inflicts Bullseye on weak spot hits, boosting crit rate and potential vulnerability.
- High crit chance for rapid follow-up damage.
- Long-range weapon with increased accuracy.
Recurve Crossbow
This versatile weapon is highly recommended for boss battles due to its ability to inflict Bullseye, increasing your crit rate by +30%. You can also mod it for Vulnerability, boosting the damage the boss takes. It’s a strong choice when combined with Mimetic Cradle skills like Master Tactician or Deviation Master, which further enhance your damage output.
- Long-range sniper with high damage per shot.
- Perfect for picking off high-value targets from a distance.
- Has a steady aim and great for precision shots.
AWS.338 – Bingo
The AWS.338 is great for its solid damage output and reliable rate of fire, making it a versatile choice against the Once Human Great Ones, especially those with weaker points at range.
- High explosive damage over a large area.
- Effective against both structures and groups of enemies.
- Perfect for crowd control and anti-vehicle purposes.
RPG7 Rocket Laumcher
Heavy weapons like the Rocket Launcher or Grenade Launcher are indispensable for their area-of-effect damage, which is crucial when dealing with bosses surrounded by minions or when you need to create space. The explosive damage can break through enemy shields and defenses, especially in encounters where the Once Human Great Ones’ minions or multiple phases of the fight demand quick crowd control.
Once Human Great Ones: Weak Points and Targeting
Ravenous Hunter
Ravenous Hunter’s Weakness
Weak Point: Yellow sac on head
This glowing sac is the boss’s main vulnerability and lights up during key attack windows, especially between its Gatling shield and rocket barrage. Hitting this spot interrupts certain attacks and massively boosts damage dealt. When it starts spitting acid or spawning adds, keeping consistent pressure on the sac can shorten the phase and reduce chaos.
Treant
Treant’s Weakness
Weak Points: Female host on back, horned head, red vines
The Treant’s back is the priority target, where the female host is embedded. The head glows during charge-ups and slams, while the red vines pulse during vulnerability phases. These areas open up temporarily after she launches flying orbs or during the slam attack wind-up. Targeting them precisely reduces the boss’s stun threshold and pushes her into her next vulnerability cycle faster.
Arachsiam
Arachsiam’s Weakness
Weak Points: Purple spots on back, human torso and head
The glowing purple sacs on its back are your main opening during its normal phase. These rupture when damaged enough, disrupting web attacks and limiting cocoons. During the mist phase, the human head and chest exposed in front become new weak points—perfect for high-burst weapons like shotguns or bows. Time your attacks during its recovery from poison cloud bursts to hit clean shots.
Rabizex
Rabizex’s Weakness
Weak Points: Head (when enraged), shoulders (after 2 HP bars)
At first, Rabizex doesn’t expose a clear weak point. Once it enters the rage state—usually after it burrows—the head glows and becomes the prime target. After two health bars are gone, the shoulders expose themselves between AoE phases. Targeting them helps reduce orb charge buildup and shortens the time between pulls. During orb-phase, missing shots means risking a one-shot wipe, so accuracy here really matters.
Secret Servitor
Secret Servitor’s Weakness
Weak Points: Glowing engine core on chest, headplate during overcharge
The Secret Servitor doesn’t waste time showing off—its weak points are mechanical and ruthless. During its standard phase, the glowing core in the chest is your main target. It pulses before the boss charges its railgun or missile salvo, and if you break it early enough, you can interrupt the sequence entirely.
Once Human Great Ones have weak points that glow, signaling where to deal maximum damage. These points might not appear immediately and may require breaking down defenses or depleting health bars first. Stay alert for these moments, and focus your attacks on glowing areas.
Using ranged weapons like the Recurve Crossbow is effective for hitting weak points from a safe distance. Understanding when and where to target these spots is crucial for defeating bosses efficiently. Follow this strategy, and you’ll be well on your way to victory.
Once Human Great Ones: Recommended Gear and Mods
When preparing for Once Human Great Ones, choosing the right gear and mods can make all the difference. For armor, the Renegade set is ideal for stacking damage, while the Agent and Scout sets grant bonuses to weak spot and weapon damage, respectively. The Heavy Duty set boosts Elemental damage, and the Falcon set increases critical damage and crit chance.
For unique pieces, the Beret adds a shrapnel hit part, perfect for extra damage, and the Mayfly goggles boost Power Surge triggers (though they reduce its damage). The Frost tactical vest is a great option for those using Frost Vortex, generating ice spikes that deal Frost damage.
As for mods, focus on those that enhance weapon damage, critical chance, or weak spot damage. These mods can be found in Silos and boss drops, with Hard Mode Silo runs offering double mod drops. Using the right mix of gear and mods will make your Once Human Great Ones encounters far more manageable.
Once Human Great Ones: Utilizing Deviants
Lone Wolf’s Whisper
Harveseed
Deviant Effect Where to Obtain Lone Wolf’s Whisper Grants weapon damage and distracts enemies by creating clones that hold aggro. Rabizex boss Harveseed Provides materials to craft Living Armor potions, preventing death once every 10 minutes. Treant bossDeviants are powerful allies in your fight against the Once Human Great Ones, providing crucial combat support. The Lone Wolf’s Whisper, for instance, boosts weapon damage and serves as a perfect distraction during mob phases. When it creates clones, you can recall the deviant, leaving the clones to hold aggro and allowing you to focus on dealing damage. It’s a must-have for managing crowd control and can be obtained from the Rabizex boss.
The Harvest Seed, obtained from the Treant boss, is another essential deviant. It provides materials for crafting Living Armor potions, which are invaluable for surviving one-shot mechanics. The potion grants a shield that prevents death once every 10 minutes for up to 1.5 hours, making it a vital tool for staying alive in tough battles.
Incorporating these deviants into your strategy will give you a significant advantage in Once Human Great Ones encounters. Whether for extra damage or lifesaving shields, they’re indispensable in challenging boss fights.
Once Human Great Ones: Learning Mechanics and Phases
Phase Key Mechanics Required Action Phase 1: Initial Phase Standard attacks, weak points, and basic moves. Focus on weak points, avoid major AoE damage. Phase 2: Immunity Stage Boss becomes immune to damage, shielded. Destroy shields or focus on adds to trigger vulnerability. Phase 3: Add Spawning Smaller enemies spawn and distract players. Eliminate adds quickly to prevent overwhelm. Phase 4: Final Phase Boss enraged, stronger attacks, faster movements. Time dodges, hit weak spots, and use high-damage weapons.Once Human Great Ones: Conclusion
The Once Human Great Ones Guide serves as your definitive roadmap for battling the most terrifying and rewarding foes in the game. These bosses, known as Great Ones, are not simple targets—they’re the heart of high-level PvE content. Mutated by Stardust and fueled by chaos, each Great One presents a unique set of mechanics, strengths, and weaknesses. Some require brute force, while others demand precision, teamwork, and a deep understanding of their behavior. From glowing weak spots to devastating enrage phases, knowing how and when to strike is the difference between victory and a frustrating respawn screen.
This guide arms you with vital knowledge: how to prepare for battles, track spawns, exploit elemental weaknesses, and maximize loot with tools like Controllers. Whether you’re a solo tactician or part of a coordinated team, the Once Human Great Ones Guide ensures you’re never walking into a boss fight blind. As you venture deeper into the corrupted world, these monstrous beings will test your builds, reflexes, and patience—but with this guide by your side, you’ll be ready to stand your ground, claim your rewards, and leave your mark on the world of Once Human.
Once Human
Play Once Human on PC and mobile for free and join your friends in a post-apocalyptic world. Fight monsters, uncover secrets, and build your own territory in this multiplayer game.
Frequently Asked Questions (FAQ)
❓What are Great Ones in Once Human?
🟢Great Ones are powerful bosses mutated by Stardust, each with unique abilities and mechanics.
❓How can I identify a Great One during gameplay?
🟢Great Ones are distinguished by a large health bar at the top of the screen, often accompanied by unique names and dramatic introductions.
❓Can Great Ones be defeated solo, or is a team required?
🟢While some Great Ones can be defeated solo with the right strategy and equipment, others are designed to challenge groups and may be extremely difficult to defeat alone.
❓Do Great Ones drop rare loot?
🟢Yes, defeating them rewards high-tier gear and valuable crafting materials.
❓Is there a recommended level to fight Great Ones?
🟢It’s advisable to approach Once Human Great Ones with a character level and gear appropriate to the boss’s difficulty to ensure a fair challenge.
